A randomized comparison of cryoballoon versus duty-cycled multielectrode radiofrequency ablation for pulmonary vein isolation

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Conference: 
2012/2013. tanév
Session: 
Cardiovascular medicine (cardiology, cardiac surgery)
Presenting author
Name (format for foreign students: Last Name, First Name): 
Lenz, Anna

Abstract data

Előadás címe: 
A randomized comparison of cryoballoon versus duty-cycled multielectrode radiofrequency ablation for pulmonary vein isolation
Abstract: 

Introduction: Cryoballoon (CB) and multipolar phased radiofrequency (RF) ablation with the Pulmonary Vein Ablation Catheter (PVAC) have been introduced as a faster and simpler procedure for pulmonary vein isolation (PVI). The available data suggest that each of these novel technologies offers similar efficacy but shorter procedure and fluoroscopy times than with point-by-point RF ablation. This study compared the acute and mid-term success and procedural parameters of CB and PVAC ablation in paroxysmal/persistent atrial fibrillation (AF).
Methods and Results: 60 consecutive patients undergoing PVAC (31 patients, age: 53±12.8y) or CB (29 patients, age: 55±12.2y) ablation for paroxysmal/persistent AF refractory to at least one antiarrhythmic drug (AAD) were enrolled. There was no difference in relevant baseline clinical parameters between the two groups. Significantly shorter procedure (104.9±38.6 vs. 135.8±31.4min), fluoroscopy(24±8.6 vs. 32±11.7min) and energy delivery (22.2±8.5 vs. 49.1±13.9 min) times were needed in the PVAC vs. the CB group, respectively. Similar success rates (97.1 % vs. 90.0%) were achieved in the isolation of the targeted pulmonary veins (PVs) and in the proportion of patients in whom of all PVs were isolated (90% vs. 79%) in both groups, but additional focal RF applications were required in 3 patients in the CB group. The atrial arrhythmia free survival at 6 months in patients off AAD was better after PVAC ablation (61.5% vs. 43.5%; p=0.02).
Conclusion: PV isolation with PVAC ablation is faster and results in a better success rate off AAD during a mid-term follow-up.

First tutor
Name: 
Dr. Csanádi Zoltán
Department: 
Kardiológiai Intézet
Second tutor
Name: 
Dr. Nagy-Baló Edina
Department: 
Kardiológiai Intézet
Prize: 
2. díj

Támogatók: Támogatók: Az NTP-TDK-14-0007 számú, A Debreceni Egyetem ÁOK TDK tevékenység népszerűsítése helyi konferencia keretében, az NTP-TDK-14-0006 számú, A Debreceni Egyetem Népegészségügyi Karán folyó Tudományos Diákköri kutatások támogatása, NTP-HHTDK-15-0011-es A Debreceni Egyetem ÁOK TDK tevékenység népszerűsítése 2016. évi helyi konferencia keretében, valamint a NTP-HHTDK-15-0057-es számú, A Debreceni Egyetem Népegészségügyi Karán folyó Tudományos Diákköri kutatások támogatása című pályázatokhoz kapcsolódóan az Emberi Erőforrás Támogatáskezelő, az Emberi Erőforrások Minisztériuma, az Oktatáskutató és Fejlesztő Intézet és a Nemzeti Tehetség Program